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About Eurogene is an Open Access e-learning system in the domain of genetics that provides free multimedia learning resources in nine languages for statistical, medical and molecular genetics and delivers them to students and professionals.   Content includes presentations, reviewed research articles, images, videos and learning packages submitted by world-leading geneticists.
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The advent of next-generation sequencing technologies is revolutionizing genetic research. Their Important applications range from genome sequencing, ChIP-seq to transcriptome analysis and small RNA discovery. Here, I will give an introduction to Illumina/Solexa sequencing platform and discuss its potential applications in genetic analysis. Data from our current projects based on Solexa sequencing, including balanced translocation breakpoint cloning, miRNA profiling and discovery, and etc, will also be presented. In the accompanying workshop, the technical details about the Illumina/ Solexa sequencing technology will be discussed.

Author: A. Read

People feel that genetics raises uniquely sensitive ethical issues. I sometimes show a diagram of the two variant PCR products from the amelogenin gene. I say that pattern A, although fairly common in the general population, is found in over 90% of the prison population, and virtually 100% of prisoners convicted for violent or sexual offences. People generally feel this raises tremendous ethical issues about personal responsibility and the justice system...

In mammalian cells DNA is packaged with histone proteins to form chromatin – a macromolecular assembly. Most nuclear processes including DNA transcription, replication and repair occur in this chromatin environment and are influenced by the packaging of the chromatin fibre. We have a good knowledge of the fundamental building blocks of chromatin, the nucleosomes, but we know little about higher-levels of chromatin organisation. Nucleosomes are comprised of eight positively charged histone proteins that can be modified by a number of marks including acetylation, methylation and phosphorylation...

The work leading to this portal has received funding from the European Community's eContentPlus Programme
under Grant Agreement n ECP-2006-EDU- 410018 from September 2007 till September 2010.